There is a grand narrative in life; humans and animals are more than mere cohabitants of the Earth; they are intertwined characters in a shared story, where the well-being of one often echoes in the other. As we delve deeper into the pages of this story, we uncover a profound truth: the health of animals and humans are inextricably linked, woven together in a delicate balance that sustains life itself. This interconnectedness supports the foundation of modern nonclinical research, where the study of animal health serves as both a mirror and a guide to understanding human health.
Nonclinical research safeguards human health while also promoting and improving animal welfare, supporting a world where both coexist harmoniously. This approach underscores the “One Health” concept, which recognizes the interconnectedness of animal, human, and environmental health.
Diseases that affect animals can often affect humans through zoonosis. Approximately 60% (CDC Yellow Book 2004) of emerging human infectious diseases are zoonotic, highlighting the need for integrated approaches to health research and management.
The recent COVID-19 pandemic, which is believed to have originated from animals, highlights the necessity of understanding animal health to prevent and control outbreaks that can affect human populations. By studying animal health, we identify potential threats and develop preventive measures, ensuring the well-being of both species.
Animal Health Studies serve as the cornerstone of healthier outcomes, ensuring that new drugs or substances are safe and effective for our companion animals . In addition to palatability investigations, Attentive scientists identify potential risks and determine appropriate dosage levels for regulatory submissions thereby laying the foundation for treatments and preventive care that keep the welfare of our four-legged friends front and center.
There are fundamental differences between human and companion animal therapeutic safety testing. Members of the Attentive Science team have extensive experience performing Bioequivalence and Target Animal Safety studies in appropriate test systems conducted under the principles of Good Laboratory Practices (GLP). A margin of safety (MOS) study is required to demonstrate substantial evidence of safety to support regulatory approval of veterinary medicines. According to the Center for Veterinary Medicine (CVM) Guidance for Industry #185/VICH GL43, the MOS study design should assess the potential risks linked to multiples of the therapeutic dose. Attentive scientists help develop and execute comprehensive strategies to meet regulatory requirements.
By fostering a deeper understanding of animal health and its relationship to human health, preclinical research will continue to play a pivotal role in advancing remedies and having therapeutics designed for use in human diseases to be approved for use in animals and vice versa.
As we look to the future, the principles of One Health will guide us towards more integrated, ethical, and impactful research, ultimately leading to a healthier world for all.
Together, we can achieve healthier outcomes for both animals, humans and the environment. Contact us for more information.